Formulation Development and Evaluation of Colonspecific Esomeprazole Microspheres

The development of Esomeprazole microspheres using enteric coated polymers, such as Eudragit L100, by antisolvent precipitation method has been the focus recent research in order to achieve best drug concentration along with improved stability and bioavailability without any adverse effects an acidic environment. For microsphere, a 32 factorial design was used, polymer amount rpm being variables. According results investigation, it found that substantial impact on release while stirring speed large entrapment efficiency. Increased L100 caused medication increase from 81.06 95.71%. optimized formulation then assessed for additional surface morphology, particle size, PDI, Zeta potential, percent efficiency, in-vitro investigations studies prepared formulation. scanning electron microscopy optimised batch, developed microparticles smooth surfaces spherical shapes were found. 93.40% 70.63% efficiency batch. As result, current study's findings indicated microencapsulation had significant benefits enhancing Esomeprazole's acid stability. By providing delayed effect duration 10 hours higher patient compliance rate, demonstrated be efficient protecting drugs media.